Ishkanah, Broodmother and Toralf's Disciple both have effects utilising Arena's greater flexibility to bring in extra cards from outside the game, while Forsaken Crossroads has extra utility if you're not the starting player - speaking to the increased pace and potential first-turn advantage in MTG Arena
In practice, this will likely mean your opponents will play all their artifacts and creatures tapped, but that's still a big effect for a two-mana vampire soldier
While yes, the Street Fighter Secret Lair is interesting and fun, their abilities seem very clunky for a deck like Sisay
It can be so egregious in some cases that theyll be flagged as Marked Cards by official Judges
In the original games, it is a revive item, restoring a fallen ally, but with minimal health