So, in Commander, Karn functions less as a finisher and more as a control lever that warps the table around him
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It works particularly well with proliferate effects to keep the Duplicate around longer than three turns, but those turns are often enough when copying high-impact threats like Hullbreaker Horror or Archon of Cruelty
For example, if you have 3 life and an effect says that your life total "becomes 10," you would gain 7 life which Phial doubles to 14, so your life total will actually become 17