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disrupts YAP-TEAD interactions and enhances trypsin cleavage of YAP with EC50 ~100 nM
PubMed Central PMCID: PMC5797615
Formula: C17H13Cl2NO4
082 nM (in membrane-assay/in cell-basedγ-secretase assays)) and also inhibits Notch clevage (IC50= 0
Further biological explorations revealed the ability of indirubin to bind cyclin-dependent kinases and 6-bromoindirubin
Haloperidol D4 Size:Solid 10 mg disrupts YAP-TEAD interactions and enhancesHaloperidol D4 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist. Product information CAS Number: 1189986 59 1 Molecular Weight: 379. 89 Formula: C21H23ClFNO2 Chemical Name: 4 {4 [4 chloro(2,3,5,6 H)phenyl] 4 hydroxypiperidin 1 yl} 1 (4 fluorophenyl)butan 1 one Smiles: [2H]C1=C(Cl)C([2H])=C([2H])C(=C1[2H])C1(O)CCN(CCCC(=O)C2C=CC(F)=CC=2)CC1 InChiKey: LNEPOXFFQSENCJ KDWZCNHSSA N InChi: InChI=1S C21H23ClFNO2
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