Instead of spells resolving in complete batches, players could now interact on the stack at any point, interrupts were removed from the game, combat damage used the stack, and the rules deactivating tapped artifacts and preventing tapped blockers from dealing damage were removed
Strefan then lets you exchange your Blood tokens for whatever powerful Vampires are lurking in your hand
That said, this seems unlikely, and if it does happen, I imagine it will be more the fault of Emrakul than anything else
He becomes an above-rate creature as soon as you have more than three lands out, which is easily done thanks to the first ability
Essentially, you have two options here: spend 2 generic and a black to destroy a creature, or spend exactly GWB to destroy any nonland permanent