Cards like Hard Evidence or Shambling Ghast or soft removal spells like Shattered Ego have a similar impact on my decision
I do want to note a unique interaction red has with the life gain theme, which is that its big damage-dealing spells can be granted lifelink by either Judith, Carnage Connoisseur or Firesong and Sunspeaker if you want to get absolutely weird with it
Goblin Charbelcher Heres the recipe for MTGs most glass cannon deck: Goblin Charbelcher, a bunch of free or fast mana la Lotus Petal, Dark Ritual, and such, and a deck with no lands, which is achievable via MDFCs
Defiant Strike occasionally sees play in decks that just need targeting spells, and while Honor is a sorcery, a +1/+1 counter is a pretty good output on a 1-mana cantrip
Icy Manipulator isn't broken or unfair, it's just a good solid card