I dont think this is really going to fly but combining this with Oblivion Ring, Leonin Relic-Warder, and related effects leads to a four card combo that will mill the opponent out on the spot using only cards that have decent utility all by themselves (other than the Altar, of course)
There are also quite a few archetypes where being able to cast the creature side to pressure an immobilized opponent is a crucial feature in favor of Simian Spirit Guide and who among us cannot smile at that thought
Mishra's Bling Bling
That said, she does make attacking a bit more advantageous with the lifelink since it can keep you in the clear while some of your creatures tread between the graveyard and your hand
For creature matchups, we have a motley crew of blue cards, with So Tiny being our Sword to Plowshares, Warrant // Warden often permanently answering a creature since we can put it on top of our opponent's deck and then mill it away, Run Away Together offering some fun tricks where we can bounce our opponent's best thing and one of our enters-the-battlefield mill creatures, and Flood of Tears being our (very bad) Wrath of God