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For example, an ability that triggers whenever you sacrifice a creature triggers only once

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Not quite the traditional Fling effect (here your opponent can remove the sacrificed creature in response to casting the spell), but it has upsides in that the creature itself deals damage to the target, so deathtouch or lifelink will work (as will abilities that trigger when the creature deals the damage)

Otherwise, you could conceivably KO anything out there while surviving most hits in return

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