This can be before blockers are declared, after blockers are declared but before combat damage is dealt, during combat after combat damage is dealt, during the postcombat main phase, during the end step, or, in some unusual cases, during the cleanup step
Partnering with Bethesda Softworks, Wizards of the Coast will feature the post-apocalyptic world of Fallout within Magic: The Gathering through another Universes Beyond Eternal-legal format set
Still, played relatively early, I suppose that damage could open a path to take down its defense counters
7 Heroic Intervention Heroic Intervention is a fairly expensive but hugely powerful instant that can save an entire board state from destruction
Boardwipes are annoyingly scarce, which means curve-out decks are well placed to take over games