Wall of Blossoms (Ext, S, Block) The highest placing true cantrip on the list, Wall of Blossoms plays defense with the best of them, without costing you a single card
Once a powerhouse in the competitive scene, Bitterblossom takes your life and makes it a resource, generating Faerie Rogue tokens at the beginning of your upkeep (and all for the low, low cost of one life)
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While it provides a unique effect, cards like Clone or Clever Impersonator may offer more flexibility in certain situations, depending on the deck's strategy
Like so many other dungeon delvers, I have dozens of stories of D&D campaigns sent screaming off the rails into the void with the party discovering a Deck in some dusty treasure hoard