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So what does Fact or Fiction mean for Modern

It wont replace any removal, but it might either become a one-of in main decks, or replace Annul in sideboards

While it's likely a bad fit for your K'rrik, Son of Yawgmoth storm deck and other black decks that aren't running many creatures, Contamination is perfect for commanders like Nath of the Gilt-Leaf that can play green mana dorks and reliably produce creatures to sacrifice to keep it around

Just be careful that you dont swear at yourself on camera because you forgot about the non-Angel part and tried to target your Karmic Guide (example definitely not taken from real-world experience)

So, put your thinking cap on, since the world is your oyster